Using the Oncomine database (https://www.oncomine.org) [22], we explored synemin mRNA expression across multiple head and neck cancers and found that synemin was significantly upregulated in head and neck cancers compared to normal tissue, as shown in Figure 2A. In line with these data, synemin was amplified in several squamous cell carcinomas, such as HPV negative HNSCC, lung squamous cell carcinomas (LUSCC) and cervix squamous cell carcinomas (CESCC), as shown in Figure S6A. This evidence concerns the gene SYNM and head and neck squamous cell carcinoma.