PTEN and colorectal cancer: Several studies using different types of cancer cell lines have shown that PTEN overexpression can increase apoptosis in glioblastoma [82], inhibit proliferation and promote apoptosis of hepatocytes [83], improve cisplatin-resistance of ovarian cancer by upregulating a downstream molecule named as keratin, type I cytoskeletal 10 (KRT10) [84], and having a cooperative role with lithium for reducing colorectal cancer, suggesting their potential combination as a novel treatment [85].