PTEN and autism spectrum disorder: Some phenotypic analyses of small clinical cohorts of PTEN mutation carriers, combined with laboratory studies of the consequences of these mutations imply that stable catalytically inactive PTEN mutants may lead to the most severe phenotypes and to a higher number of lesions and, conversely, that mutants retaining partial function or with truncating mutations associate more frequently with a milder phenotype, with autism spectrum disorder often being diagnosed [87,101].