The risk factors for SGLT2 inhibitors-associated DKA are those conditions leading to restricted food intake or severe dehydration, alcohol abuse, sudden reduction in insulin or increased insulin requirements due to acute illness such as low beta cell function reserve (patients with T2DM who have low C-peptide levels, latent autoimmune diabetes in adults (LADA) or a history of pancreatitis) [108]. This evidence concerns the gene INS and pancreatitis.