Here, the different studies revealed interactions of Notch with the classical (canonical) NF-κB pathway in which heterodimers of IκB kinase α (IKKα) and IKKβ lead to activation of p50 and p65 (RELA), typically induced by pro-inflammatory cytokines such as TNFα and IL-1β and infection-related signals. This evidence concerns the gene NFKB1 and infection.