For example, evidence from our studies indicated that co-culturing of TNBC cells with mesenchymal stromal cells (MSCs) or cancer-associated fibroblasts (CAFs) in the presence of TNFα or IL-1β stimulation has given rise to contact-dependent increase in CXCL8, CCL2 and CCL5 levels in the co-cultures. The gene discussed is CXCL8; the disease is cancer.