RBPJ and breast cancer: In parallel, it was found that the terminal differentiation of macrophages to TAMs—that did not demonstrate the alternatively activated phenotype of M2 macrophages—depended on recombination signal-binding protein for immunoglobulin kappa J region (RBPJ) [86], known to act together with Notch intracellular domain (NICD) in gene expression regulation [87]; in turn, these RBPJ-expressing TAMs were found to down-regulate the levels of granzyme-expressing CD8+ T cells and to elevate tumor burden in a BC model [86].