ESR1 and cancer: Specifically in the cancer cells, many different levels were positively affected by the Notch-inflammation networks, such as: increase in metabolic processes; CSC expansion; elevated tumor cell proliferation; increased EMT, migration and invasion; higher resistance to hypoxia and endocrine treatments, and transcription of ERα-responsive genes; and elevated release of pro-inflammatory /metastasis-promoting factors such as IL-1β, IL-6, CCL2, CXCL8 and TGFβ.