In parallel, different studies indicated that the pro-inflammatory mediators TNFα and IL-1β, as well as the inflammatory chemokines CXCL8 (IL-8), CCL2 (MCP-1) and CCL5 (RANTES)—that are major contributors to BC progression [45,74,75,76,77,78,79,93,94,95,96]—were connected to Notch activities in BC. The gene discussed is TNF; the disease is breast cancer.