This is illustrated for example by studies on tumor initiation (Notch1; Notch3), stem cell control (Notch1; Notch4; Jag1; Jag2; DLL1), angiogenesis (Notch1; DLL4) invasion and metastasis in remote organs (Notch1; Notch2; Jag1; DLL1) [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39]. This evidence concerns the gene NOTCH3 and neoplasm.