SOCS3 and fibrosarcoma: The JAK/STAT pathway directly communicates through STAT3 and the suppressor of cytokine signaling 3 (SOCS3) with the Rapidly Accelerated Fibrosarcoma/Ras-extracellular signal-regulated kinase (RAF/RAS/ERK) and the Phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathways [64,65] (Figure 1).