Its involvements in cancer are emerging too: in melanoma by acting on key master regulators of the signaling pathway [199]; in papillary thyroid cancer by sponging hsa-miR-324-3p and up-regulating LIM and SH3 domain protein 1 (LASP1) [122]; in colorectal cancer by regulating the miR-132/Derlin-1 pathway [121]. The gene discussed is DERL1; the disease is thyroid gland papillary carcinoma.