In particular, OCT4-pg4 is located in chromosomal region 1q22, frequently amplified in hepatocellular carcinoma and this Ψ-gene isoform, lacking the 3’UTR original region, harbors seed matches for miR-145 in the portion of sequence deriving from the coding sequence of the parental OCT4. Its high expression in hepatocellular carcinoma is able to sequester miR-145 molecules and, therefore, to de-repress OCT4 leading to the coding gene aberrant high expression in this context [117]. The gene discussed is POU5F1; the disease is hepatocellular carcinoma.