New observations have emerged in the control of immune checkpoint molecules: through hsa-miR-150-5p sponge interaction, lncRNA-MIAT, together with HLA complex P5 (HCP5), has been associated with the up-regulated expression of PD-L1/CD274, suggesting new involvements in the field of tumor immunity and immunotherapy [123]. The gene discussed is HCP5; the disease is neoplasm.