CDKN2A and cancer: The five genes that are the focus of this work encode known tumor suppressors that have been suggested to be silenced by methylation in cancer: Cyclin-Dependent Kinase Inhibitor 2A/p16 (CDKN2Ap16), Telomerase Reverse Transcriptase (TERT), RAS-association domain family 1 isoform A (RASSF1A), E-Cadherin (CDH1), and Wilms’ Tumor 1 (WT1).