In the present study, we demonstrate increased plasma clusterin levels after ischemic myocardial injury (120 min after AMI onset) that returned to normal levels already after 3 days, suggesting that it can be a similar and additionally early and high-sensitive biomarker of acute myocardial ischemia as hs-cTn, which increases 2–3 h after ischemia onset and remains elevated several days after AMI. This evidence concerns the gene CLU and ischemia.