Based on contradictory data on the above-mentioned biomarkers in AMI we aimed to further clarify the dynamics of clusterin, neprilysin, NGAL, osteopontin, ET-1, miR21 and miR29 in a preclinical porcine model of reperfused AMI in which duration and extent of myocardial ischemia are standardised and comparable, and associated with cardiac magnetic resonance imaging (cMRI)-derived cardiac function parameter. The gene discussed is CLU; the disease is myocardial ischemia.