Histone deacetylase (HDAC) inhibitor drugs, including trichostatin A, were found to repress melanin synthesis through transcriptional downregulation of the melanocyte-specific isoform of MITF (M-MITF) in melanocytes, melanoma, and clear cell sarcoma cells, and topical application of trichostatin A suppressed skin pigmentation in mice [17]. This evidence concerns the gene MITF and clear cell sarcoma.