A previous study by our group aimed to identify targets for improving the therapeutic efficiency of radiotherapy and overcoming IR-induced invasion/migration by focusing on modulating cancer-specific physiological changes, such as the tumor microenvironment (TME), following IR treatment [29], which resulted in the identification of a novel EGFR–p38/ERK–STAT3/CREB-1–EMT pathway. The gene discussed is STAT3; the disease is cancer.