In view of another recent report that TNF-related apoptosis-inducing ligand (TRAIL) activates the Src-STAT3 pathway to induce invasion/migration in NSCLC cells [24], we postulated the possibility of a relationship between EGFR and Src-STAT3 in the IR-induced increase in invasion/migration. Here, STAT3 is linked to non-small cell lung carcinoma.