P2RY12 and Stroke: A 2016 expert consensus document recommended single antiplatelet therapy with P2Y12 inhibitor over aspirin because of the pivotal role of P2Y12-mediated signaling in thrombotic and inflammatory processes; the established clinical role of P2Y12 inhibitors in reducing ST; its favorable efficacy profile regarding prevention of stroke, MI, and mortality; and better gastro-intestinal tolerance.