Emerging data suggest that olaparib-resistant cancer models can be re-sensitized to olaparib when combined with AZD1775 or AZD6738 [85,86,87], leading to early phase clinical trials combining ATR inhibitors and PARPis in different cancers (NCT02723864, NCT03462342, NCT03682289, NCT02576444). This evidence concerns the gene ATR and cancer.