The exposure of melanoma cells to BRAF and MEK inhibitors induced the upregulation of histone methyltransferases (SETDB1 and SETDB2) [99], as well as the overexpression of histone demethylases (KDM6A, KDM6B, KDM1B, JARID1A, JARID1B) [101,102,103]. The gene discussed is BRAF; the disease is melanoma.