BRAF and neoplasm: As the concurrent inhibition of the BRAF and MEK proteins of the MAPK pathway could decrease MAPK-driven acquired resistance, leading to a longer duration of responses, a higher rate of tumor responses and a longer progression-free survival and overall survival, BRAFi/MEKis are used in clinical practice in combinations (vemurafenib and cobimetinib, dabrafenib and trametinib and encorafenib and binimetinib) resulting in median PFS and OS of 12–15 months and 22–33 months, respectively.