CYC1 and infection: Moreover, Curtoet al. [66] found that infection of THP-1 macrophages with pathogenic Rickettsiae resulted in the accumulation of proteins involved in the electron transport chain including cytochrome C1 (CYC1), ubiquinol-cytochrome c reductase core protein 1 and 2 (UQCRC1 and 2), cytochrome c oxidase subunit 4l1 (COX4l1) and cytochrome c oxidase subunit II (COX2).