ADM and amyotrophic lateral sclerosis: The pathway analysis of the 364 DEGs between HNF4α+/Δ and control cells (FC ≥ 2, p < 0.05) inferred that pathways involved in transducing cellular stress (such as GP6 and the Amyotrophic Lateral Sclerosis Pathway), cell survival (such as the Adrenomedullin Signaling Pathway, the activation of which is linked to growth stimulation and apoptosis inhibition) and differentiation (such as Wnt/β–catenin signaling) were all predicted to be activated based on the observed transcriptome landscape (Figure 6B).