This regulates cell growth, differentiation, apoptosis and cancer progression by directly binding to miR-615-3p and acting effectively as an endogenous sponge to modulate the suppression of IGF-2 in renal carcinoma [19] or the expression of high mobility group box 3 (HMGB3) in NSCLC cells [21]. This evidence concerns the gene HMGB3 and renal carcinoma.