The IGF-axis is also modulated by miR-615-5p in NK cells of hepatocellular carcinoma (HCC) patients, in which upregulation of miR-615-5p directly represses IGFR1 signaling and reduces the cytotoxic markers NKG2D, TNF-a and perforins. The gene discussed is TNF; the disease is hepatocellular carcinoma.