CASP3 and posterior cortical atrophy: We then wanted to confirm that JNKi induces apoptosis; indeed, it is noteworthy that JNKi treatment led to the activation of cleaved caspase 3/7 in DU145 and PC-3 PCa cells (Figure 1D, n = 3, DU145 cells: *** p = 0.0009 for caspase 3, p = 0.0539 for caspase 7; PC-3 cells, all conditions **** p < 0.0001 for DU145 and PC-3 cells).