TNF and obesity due to melanocortin 4 receptor deficiency: Further, Oh et al. recently showed that a spice blend supplement (6 g) taken with a HF, high-carbohydrate meal reduced IL-1β, IL-8, and tumor necrosis factor-α secretion by liposaccharide-stimulated (LPS) peripheral blood mononuclear cells of men who had overweight or obesity [58].