ENO2 and neoplasm: The currently used diagnostic tools—i.e., chest radiography and sputum cytology—are not sensitive enough in the diagnosis of non-small cell lung carcinoma (NSCLC), while tumor markers, such as CEA (carcinoembryonic antigen), CYFRA 21-1, NSE (neuron-specific enolase), or SCCA (squamous cell carcinoma antigen) do not make the diagnosis possible at the early stage of lung cancer [4].