A head-to-head Abatacept versus adaliMumab comparison in biologic-naïve RA subjects with background methotrexate (AMPLE) trial (ClinicalTrials.gov: NCT00929864) showed similar efficacy and tolerability for subcutaneous (SC) abatacept versus the TNF inhibitor adalimumab over two years in patients with active RA and an inadequate response to MTX [8,9]. This evidence concerns the gene TNF and rheumatoid arthritis.