As with other sHSPs, mutations in the hspb8 gene can cause diseases included in the group of inherited motor neuron diseases (MNDs) such as distal hereditary motor neuropathy (dHMN type IIA) [24] and Charcot-Marie-Tooth disease type 2L (CMT2L) [25]. This evidence concerns the gene HSPB8 and Charcot-Marie-Tooth disease axonal type 2L.