Regarding exercise, a recent meta-analysis found decreased fetuin A levels following completion of aerobic exercise regimes of varying frequency and duration (e.g., 1–12 weeks, 3–5 sessions per week of 40–70 min each) and intensity (e.g., 60–85% maximum heart rate), except in patients with T2DM, suggesting that modulation of fetuin A by exercise partially depends on the pre-existing metabolic status [138]. The gene discussed is AHSG; the disease is type 2 diabetes mellitus.