The second clinical trial (phase II) is evaluating the side effects and best dose of Nivolumab and Azacitidine with or without the anti-CTLA-4 antibody Ipilimumab in patients with treatment-refractory, relapsed or newly diagnosed AML (ClinicalTrials.gov Identifier: NCT02397720). This evidence concerns the gene CTLA4 and acute myeloid leukemia.