NLRP3 and chronic myelomonocytic leukemia: Regarding increased pro-inflammatory signaling, one publication reported the oncogenic KRASG12D mutation as a driver for elevated myeloproliferation and chronic myelomonocytic leukemia (CMML) through activation of the NLRP3 inflammasome and caspase-1-mediated cleavage of pro-inflammatory cytokines [38,39].