Regarding increased pro-inflammatory signaling, one publication reported the oncogenic KRASG12D mutation as a driver for elevated myeloproliferation and chronic myelomonocytic leukemia (CMML) through activation of the NLRP3 inflammasome and caspase-1-mediated cleavage of pro-inflammatory cytokines [38,39]. The gene discussed is CASP1; the disease is chronic myelomonocytic leukemia.