Within the three major types of MPN, genetic abnormalities drive neutrophil gene expression causing an activation of inflammatory signaling pathways with elevated secretion of IL-6, IL-1β, interleukin-8 (IL-8), interleukin-11 (IL-11), interleukin-17 (IL-17), TNFα, transforming growth factor β (TGFβ) or granulocyte-macrophage colony-stimulating factor (GM-CSF) [4,43,57,58,59,60,61,62]. Here, CSF2 is linked to myeloproliferative disorder.