On the other hand, PD-L1 (B7-H1), a transmembrane glycoprotein included in the B7 family of immune regulatory molecules [6], is constitutively expressed on inflammatory-activated immune cells such as macrophages, T-and B cells, and endothelial and intestinal epithelial cells and is also inducible in many other cells, particularly cancer cells in the presence of certain pro-inflammatory stimuli [7]. Here, CD274 is linked to cancer.