Medications for T2DM also work by decreasing hepatic glucose production and increasing insulin-mediated glucose uptake (e.g., metformin), as well as by inhibiting enzymes that catalyze the degradation of lysosomal glycogen (e.g., alglucosidase alfa) or the degradation of insulinotropic hormones [5]. This evidence concerns the gene INS and type 2 diabetes mellitus.