Other approaches to combat HIV-1 infection include novel strategies such as disrupting the CCR5 gene in human hematopoietic stem/progenitor cells (HSCs) [25] using zinc finger nuclease-mediated CCR5 knockout, or in CD4+ T cells or HSCs using CRISPR/Cas9 genome editing [26,27]. The gene discussed is CCR5; the disease is HIV-1 infection.