Neuropathy in hereditary gelsolin amyloidosis (HGA) might be caused by both amyloid formation and loss of function of the gelsolin protein [98], since gelsolin is a key regulator of actin filament assembly and disassembly [99,100], and in neurons these processes govern spine formation, morphology, and synaptic functions [101]. The gene discussed is GSN; the disease is human granulocytic anaplasmosis.