LRRK2 and Parkinson disease: Interestingly, some of the mutations linked to familial PD, such as that on leucine-rich repeat kinase 2 (LRRK2) or PTEN-induced putative kinase 1 (PINK1) genes, are involved in mitochondrial dysfunction and in the disruption of the redox homeostasis in neurons [216], highlighting the relevance of the oxidative stress in the PD progression [232].