CXCL12 and neoplasm: Specifically, BCAF-derived SDF-1 and TGF-β, via Src activation, induce the formation of multicellular clusters composed of two distinct tumor cell populations: one is composed of tumor cells in a highly epithelial (Ehi) state, as exemplified by the upregulation of the epithelial marker E-cadherin and the oncogenic cell–cell adhesion molecules, CAM5 and CAM6.