IGF1R and breast cancer: Noticeably, ongoing clinical trials targeting the IGF/IGF-1R pathway in BC patients are exploiting anti-IGF-1R monoclonal antibodies (such as dalotuzumab, figitumumab, cixutumumab, ganitumab, R1507, AVE1642), anti-IGF-I and IGF-II monoclonal antibodies (MEDI-573 and BI 836845), and a small IGF-IR-tyrosine kinase inhibitor (OSI-906) as a strategy to slow down, and, in the best case scenario, to block metastatic spread [218].