PPARG and Insulin resistance: A previous study has shown that under ligand stimulation, the Ala subtype of PPARG2/RXR heterodimer lessens the functioning of PPARG2 in adipose tissues, thereby decreasing the levels of fat accumulation and resulting in a lower risk of insulin resistance; however, under conditions with no ligand stimulation, there were no significant differences between the Pro and Ala subtype heterodimers in fat accumulation or insulin resistance [18].