AKT1 and melanoma: The clinical significance of miR-200c/Bmi1 axis in inhibiting acquired resistance to BRAFi was confirmed in human melanoma tissues: loss of miR-200c expression was found to correlate with development of resistance to BRAFi and promote the development of a BRAFi-resistant phenotype in melanoma cells and in melanoma tissues with a mechanism that involves MAPK and PI3K/AKT signaling pathways [60].