These Authors found that resistance to BRAFi and MEKi associates with induction of PD-L1 expression in BRAF(V600E)-mutated melanoma cell lines and identified the post-transcriptional circuit responsible for PD-L1 up-regulation, consisting of a direct interaction of miR-17-5p with the 3’UTR mRNA of PD-L1 [93]. The gene discussed is CD274; the disease is melanoma.