By a microarray-based profiling performed in PD1+ and PD1- CD4 T cells sorted from lymph nodes and spleen of melanoma-bearing mice, Li and colleagues demonstrated that miR-28 decreases PD1 expression by directly binding to its 3’UTR, suggesting that miR-28 regulates exhaustive differentiation of Treg in melanoma cells. This evidence concerns the gene CD4 and melanoma.