miR-222 directly interact with 3’UTR of the Intracellular Adhesion Molecule 1 (ICAM1) mRNA [77] which, consequently, affects melanoma immune resistance by rendering melanoma cells more resistant to TIL-mediated killing mainly due to their ability to cross endothelial vessels and infiltrate tumor tissues [78,79]. This evidence concerns the gene ICAM1 and melanoma.