CDKN2B and coronary artery disorder: Lastly, genetic association studies of CAD independently identified the 9p21 susceptibility locus, which is adjacent to the lncRNA CDKN2B-AS1 (also known as ANRIL), and hundreds of kilobases from the protein-coding genes CDKN2A and CDKN2B. Although the biological function of ANRIL and the nearby disease-associated variants is incompletely understood, recent studies have provided evidence for its role in CVD [101,106,107,112]—mechanistic insights into such complex genetic loci will be the focus of the next section.