Network analysis of the other de novo mutations (KSHV (-) tumor associated mutations) points to the existence of a PDGFRA-Rac1 driven network that is consistent with the Rac1 overexpression in AIDS-KS [32] and mECK36 KSHV (+) and KSHV (-) tumors as well as the proposed role of ROS in AIDS-KS as shown by mECK36 NAC sensitivity [23]. The gene discussed is RAC1; the disease is neoplasm.