We found that the PDGFRAD842V mutation, which was described in GIST as a driver mutation, also was a driver mutation in our KSHV (-) tumors further supporting the idea that PDGFRA is a key oncogenic driver in KSHV tumors, that in its activated mutated form can compensate for KSHV loss [22]. The gene discussed is PDGFRA; the disease is gastrointestinal stromal tumor.