APC2 and neoplasm: During tumor growth without the virus we detected hyper-methylation of three repressors of the Wnt signaling, the tumor suppressors and the antagonists of the Wnt signaling, APC [43] and APC2 [44], and Tle2 a transcriptional corepressor that binds to and Inhibits the transcriptional activation of CTNNB1 and TCF family members that mediate the Wnt signaling [45].