Four of these had a stronger effect on the age-of-onset of eczema: those in/near HRNR (rs1213821), FLG (rs61816761), TCHHL1 (rs115045402), SPRR2A (rs184587444), all within a 1 Mb locus on chromosome 1q21. This evidence concerns the gene TCHHL1 and Eczematoid dermatitis.