TCHHL1 and asthma: The exceptions were four variants located on chromosomes 1q21.3 (in/near TCHHL1, HRNR, FLG and SPRR2A) which had significantly stronger effects on age-of-onset of eczema, and one on 17q12 (in GSDMB) which had a stronger effect on the age-of-onset of asthma (Fig 2).