On the other hand, most 15 of the 26 sentinel variants identified in the multivariate GWAS represent novel associations for allergic disease (Table 1 and S8 Table), including for example rs7565907 in LCLAT1and rs11242709 near DUSP22. Thus, overall, by considering age-of-onset information, we identified 18 (3+15) novel genetic associations for allergic disease. Here, DUSP22 is linked to allergic disease.