Mutations in WNK1 and WNK4 are associated with familial hyperkaliaemic hypertension (FHHt) or pseudohypoaldosteronism type II (PHAII) (OMIM: 145260) as a result of increased NCC activity.26, 27, 28. The gene discussed is SLC12A3; the disease is pseudohypoaldosteronism type 2.