Although there was a partial recovery in the turning behavior at 6 weeks following 6‐OHDA injection except for p‐CaMKIIδ3 expression, our results indicated that APα treatment could further improve the motor performance in PD mice, accompanying with a significant increase in TH‐positive neurons and their fibers or dopamine levels, as well as the number of NPCs. This evidence concerns the gene TH and Parkinson disease.