Most frequently mutated genes were TP53 (10.1% of all variants), ARID1A (7.4%), AKT1 (6.8%), GATA3 (6.4%), and MAP3K1 (6.4%) in tumor (Figure 1A, Figure S4) and TP53 (8.6%), PIK3CA (5.2%), GATA3 (4.0%), ARID1A (3.7%), FGFR1 (3.7%), and MAP3K1 (3.7%) in cfDNA (Figure S5). Here, PIK3CA is linked to neoplasm.