CD40 and neoplasm: When they subsequently divided the HPV-related OPSCCs into two groups based on the amount of B cell infiltrate (Blow (B cell proportions < 0.5% of total cells) versus Bhi tumors), they noticed that in the Bhi group the tumor-infiltrating B cells displayed significantly higher levels of activation markers like HLA-ABC, HLA-DR, CD86, and CD40 when compared with the Blo group, corresponding with an activated phenotype.