Echarti et al. recently reported high stromal numbers of Tregs to be correlated with improved survival in HNSCC, and epithelial numbers of Tregs to only gain prognostic importance when stratifying for “inflamed”, “immune excluded”, and “immune desert” tumors based on total number of infiltrating CD8+ T cells [126]. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.