CD4 and neoplasm: Mature B cells can produce antibodies which could bind to tumor cells and induce ADCC by NK cells or Fc-receptor mediated phagocytosis by macrophages, they can also act as APCs or can directly interact with CD4+ T cells (through CD40/CD40L) or CD8+ T cells (through CD27/CD70), thereby, providing help to the anti-tumor immune response [137].