In a transcriptional study, linking TP53 mutational status in HNSCC with immune signatures, neutrophil, a NK cell, pDC, Treg, CD8+ TIL, and B cell gene signatures were reported to be significantly lower in TP53 mutated compared with TP53 wild-type tumors (P = 0.001) and higher in HRAS-mutated tumors (p = 0.033). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.