Based on expression profiling in ovarian Sertoli-Leydig-cell tumors, Wilms tumors and Uterine Corpus Endometrial Carcinoma with DICER1 RNase IIIb mutations, let-7 targets were found among the most significantly upregulated genes compared to other tumors of the same type that lacked DICER1 RNase IIIb mutations [113, 133, 138]. Here, DICER1 is linked to Nephroblastoma.