MGAT5 and spontaneous abortion: Since gal-1 promotes EVT differentiation and invasion during early pregnancy [134], it is possible that increased activity of GnTV may lead to enhanced signaling by this lectin [127]; particularly by promoting its interaction with cell surface β1 integrin [127, 135–141] Furthermore, villous tissues from early spontaneous miscarriages show a reduced abundance of such (β-6) branches together with decreased GnTV expression in comparison with healthy pregnancy villous tissues [142].