Indeed, treatment with anginex (an artificial β-peptide targeting gal-1 proangiogenic functions) resulted in decreased adhesion and capillary tube formation in SGHPL-4 EVT-like cells in vitro and impaired spiral artery remodeling and placental function in an in vivo mouse model, causing preeclampsia-like symptoms during late gestation and fetal growth restriction [47]. This evidence concerns the gene LGALS1 and preeclampsia.