TP53 and neoplasm: Meanwhile, since MTH improves blood flow in the tumor and relieves the chronic hypoxic areas that occur consistently depending on the distance from the blood vessel, it was also found that the use of TPZ combined with MTH further enhances the cytocidal effect on tumor cells, especially Q tumor cells, which are very resistant to conventional cancer therapy, again independently of the p53 status of the tumor cells [52–55].