Metformin suppresses polyp growth in ApcMin/+ Mice, and an important link between AMPK/glucose metabolism and colorectal cancer is the observation that Peutz-Jeghers syndrome involves a mutation in the LKB1 tumor suppressor gene, and the finding that LKB1 acts through AMPK for signaling [14]. This evidence concerns the gene STK11 and Peutz-Jeghers syndrome.