PDX1 and Hyperglycemia: This study is an ideal comparison to the transgenic mouse model approach carried out using Ins1−/−;Ins2f/f;Pdx1-CreER mice31 wherein following delivery of tamoxifen there was ~99% recombination efficiency, mice developed hyperglycemia two weeks post-tamoxifen, and had reduced circulating insulin four weeks post-tamoxifen.