Notably, GOLPH3 oncogene amplification at chromosome 5p13 and protein overexpression have been documented in a high proportion of human malignancies, including colorectal cancer, and frequently associated with a poor prognosis, and chemotherapy resistance, which makes it an attractive therapeutic target and raises interesting questions about how GOLPH3 and the Golgi structure integrity contribute to cancer5,11–18. This evidence concerns the gene GOLPH3 and colorectal cancer.