MTOR and cancer: We are aware that the present report has limitations that should be addressed in future works: (1) this is a basic research study which must be further confirmed by the analysis of miR-3135b and GOLPH3/AKT1/mTOR axis molecules in biopsies from CRC patients in order to evaluate their clinical value; (2) it is necessary to assess the protective role of miR-3135b in Golgi dispersal in response to other drugs and radiotherapy in a larger number of cell lines from diverse types of cancer; and (3) to characterize additional miR-3135b gene targets involved in the cytoplasmic DNA damage response.