Generally, high MBL concentrations (> 3 μg/ml) were overrepresented among patients (26%) compared with controls [4.9%, p < 0.000001, OR = 6.7, 95% CI (3.44–12.98); after multiple logistic regression analysis: p < 0.001 OR = 9.22 95% CI (3.03–28.02)] with particularly high frequency associated with hospital infections whether accompanied with bacteremia/fungaemia [26.8%, p < 0.0001, OR = 7.1, 95% CI (2.93–17.27)] or not [33.9%, p < 0.0001, OR = 9.94, 95% CI (4.58–21.59)]. Here, MBL2 is linked to infection.