However, low ficolin-2 was suggested to predict higher risk of development of sinusoidal obstruction syndrome (SOS) after allogeneic haemopoietic cell transplantation33,34 while low ficolin-3 was considered a risk factor for febrile neutropenia (also accompanied with bacteremia) in children, treated with anti-cancer chemotherapy35. This evidence concerns the gene FCN3 and spondylo-ocular syndrome.