The associations between HLA-A*0206, HLA-B*4403 and acetaminophen-induced SJS/TEN with SOC in Japanese population were reported in Ueta et al.23 Therefore, future epidemiology studies identify the risk of HLA genotypes and other distinct CM (i.e. ibuprofen) induced SJS/TEN with SOC may be necessary. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.