HLA-C and toxic epidermal necrolysis: Four studies defined CM as multi-ingredient CM including NSAIDs.23,24,34,35 All of the included studies investigated associations between 81 different HLA genotypes and CM-induced SJS/TEN with SOC (i.e., 22 different HLA-A genotype, 40 different HLA-B genotypes and 19 different HLA-C genotypes).23,24,33–36 Diagnostic criteria for SJS/TEN and SOC and definition of CM of each study are summarized in Table 2 and Supplemental Table 1.