From our systematic review, HLA-A*6601, HLA-C*1203 were associated with CM-induced SJS/TEN with SOC in the Brazilian population.34HLA-B*1301, HLA-B*4601 were associated with CM-induced SJS/TEN with SOC in Japanese population.23HLA-B*1502, HLA-C*0801 were associated with CM-induced SJS/TEN with SOC in Indian population.33 Due to limited number of studies, more studies investigating associations between these HLA genotypes and CM-induced SJS/TEN with SOC in the same or different ethnicities are needed. Here, HLA-C is linked to toxic epidermal necrolysis.