Investigations have indicated that aging men have a reduced testosterone level, which is related to an elevated pro-inflammatory condition.17 Besides, it is observed that testosterone therapy leads to a reduction in IL-6, IL-1β, and tumor necrosis factor α (TNF-α).18 Therefore, Pozzilli, et al19 proposed that through the activation of cytokine storm, testosterone may be involved in the progression of COVID-19. Here, TNF is linked to COVID-19.