Transcription factors of the erythroid, including GATA-binding factor 1 (GATA1), nuclear factor erythroid 2 (NF-E2), stem cell leukaemia pentameric complex, and Kruppel-like factor1 (KLF1) are subsequently bound to the enhancers to promote alpha-globin gene expression [7]. The gene discussed is NFE2; the disease is leukemia.