Huang et al. reported that atorvastatin pretreatment can upregulate lncRNA H19 in MSCs and their secreted exosomes, which could be utilized for treating acute myocardial infarction in rats by inhibiting the inflammatory factors, along with increased release of VEGF and enhanced MSC-mediated cardioprotective effect [59]. This evidence concerns the gene H19 and acute myocardial infarction.