In summary, we discovered the molecular regulatory network in which SRSF10 facilitated circ-ATXN1 biogenesis and subsequently increased its binding with miR-526b-3p to inhibit the negative regulatory effect of miR-526b-3p on MMP2 and VEGFA in regulating glioma angiogenesis. The gene discussed is ATXN1; the disease is central nervous system cancer.